Fig. 1: Enrichment dynamics in response to antibiotics.
a Bacterial responses to antibiotic treatment from single cells to community dynamics. In a single population, faster-growing cells are killed faster, leading to a positive linear correlation between the growth rate and the killing rate. Antibiotic treatment can lead to either an increase in the slow- or fast-growing fractions of the community, depending on growth and lysis rate correlations or subpopulation interactions, while concurrently reducing the overall population size. b Modeling the impact of interactions and variability of growth and lysis correlations on the community restructuring induced by antibiotics. When a clonal population grows under community interactions or in different environments, changes in effective growth rate alter the lysis rate along the linear correlation (growth rate modulation). Also, each subpopulation may follow a distinct linear correlation (G/L variability). Incorporating these two factors, subpopulation temporal dynamics can then be modeled. The abundance of i-th subpopulation (Si) increases and decreases with growth (Gi) and lysis (Li) rates, where the Gi accounts for logistic growth from the maximum growth rate (Gm,i) and interactions (Iij) from j-th subpopulations. Li follows a unique, strain-specific linear correlation with Gi, represented by the slope (ai) and intercept (bi).
