Fig. 2: Prolonged J-wave in the ECG was accompanied by fibrotic myocardium, shorter time to exhaustion and lower SBP in hypoxic KO mice.
From: PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice
a Electrocardiogram of WT and KO hypoxic mouse models. Red and blue lines indicated QT interval and J-wave, respectively; n = 6 for each group. b Comparison of gross heart anatomy between WT vs KO of normoxic/hypoxic mouse model. c, d Heart weight and heart-to-body weight ratio after hypoxia exposure in all four groups at 18 weeks-old; n = 8-11. e Masson’s trichrome staining of heart tissue in WT and KO of normoxic or hypoxic mouse model. f–k Right ventricle (RV) fibrosis (f; p < 0.0001), left ventricle (LV) fibrosis (g; p = 0.0002, <0.0001), RV thickness (h), LV thickness (i), RV inner circumference (j; p = 0.0011 & <0.0001), LV inner circumference (k; p = 0.0025, <0.0001) were measured. Exercise capacity (l; p = 0.0017, 0.0065) and sustained running speed, (m; p = 0.0015, 0.0015) were measured using Exer 3/6 treadmill. Systolic blood pressure (SBP; n; p = 0.035), mean arterial pressure (MAP; o) and heart rate (HR; p) were measured using tail cuff. n\(\ge\)6 for all data sets, n represents the number of mice. Statistical analysis is based on one-way ANOVA multiple comparisons, followed by Tukey’s post-hoc. Statistical significance between different groups is indicated in the graph with asterisk (*); data are presented as mean values ± SEM. Source data are provided in a Source Data file.
