Fig. 5: LV systolic pressure and function from the ex-vivo working heart system were abnormal in KO mouse model heart.
From: PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice
PV loop was studied in 14 weeks old WT and KO of normoxic or hypoxic mouse models (a). LVV left ventricle volume, LVP left ventricle pressure. Left ventricle pressure maximum (LVPmax), end systolic pressure (ESP), and end diastolic pressure (EDP) parameters were analyzed (b). Ejection fraction, stroke volume, and cardiac output were analyzed to indicate LV functions (c). Adrenalin (4 mg/L) and diltiazem (0.08 mg/L) were used as a stress test. n = 6 for all data sets; n represents the number of mice. Statistical analysis is based on one-way ANOVA multiple comparisons, followed by Tukey’s post-hoc. Statistical significance between control and treatment is indicated with asterisk (*); comparison between WT and KO is shown in hashtag (#). *p = 0.021; ****p < 0.0001; #p = 0.025; ####p < 0.0001; data are presented as mean values ± SEM. Source data are provided in a Source Data file.
