Fig. 4: TRAIP and FAN1 deficiency differently affect psoralen ICL-induced mutagenesis. | Nature Communications

Fig. 4: TRAIP and FAN1 deficiency differently affect psoralen ICL-induced mutagenesis.

From: FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations

Fig. 4

A Tornado plots and B bar graphs representing the mutational spectrum for wild-type (n = 5), fcd-2 (n = 3), fnci-1 (n = 3), xpf-1 (n = 3), xpa-1 (n = 3) and fan-1 (n = 3) mutant animals (***P = 0.0001, ****P < 0.0001; Two-Way ANOVA test, Dunnett’s multiple comparison test). Data are presented as mean values ± SD. C Tornado plots for wild-type (n = 5) and trul-1 (n = 3) mutant animals. D Area plot of the position of the deletion junctions relative to the ICL location (x-axis) for wild-type (n = 5) and trul-1 (n = 3) mutant animals. Y-axis represents the fraction of deletions within the deletion spectrum. Data are presented as mean values ± SD. Source data are provided as a Source Data file.

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