Fig. 9: Maternal behavior in the early period can mediate later-life stress resilience by a microglial-to-neuronal IGF-1-C/EBPβ-DRP1 signaling in the mPFC of adolescent mice. | Nature Communications

Fig. 9: Maternal behavior in the early period can mediate later-life stress resilience by a microglial-to-neuronal IGF-1-C/EBPβ-DRP1 signaling in the mPFC of adolescent mice.

From: Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis

Fig. 9: Maternal behavior in the early period can mediate later-life stress resilience by a microglial-to-neuronal IGF-1-C/EBPβ-DRP1 signaling in the mPFC of adolescent mice.The alternative text for this image may have been generated using AI.

In the mPFC of adolescent mice with low maternal care, social stress activates transcription factor C/EBPβ in mPFC neurons, upregulating Dnm1l expression and promoting mitochondrial dysfunction, which confers to stress susceptible in adolescent mice. However, high maternal care stimulates microglia to relieve IGF-1, which inhibit neuronal C/EBPβ activity through mTOR-induced C/EBPβ-LIP translation via binding to IGF-1R on the neurons in the mPFC of offspring, which protects stress resilience in adolescence. Source data are provided as a Source Data file.

Back to article page