Fig. 3: Associations between genetically predicted levels of 65 inflammatory markers and the risk of sarcoidosis in Mendelian randomization (MR) analysis. | Nature Communications

Fig. 3: Associations between genetically predicted levels of 65 inflammatory markers and the risk of sarcoidosis in Mendelian randomization (MR) analysis.

From: GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis

Fig. 3: Associations between genetically predicted levels of 65 inflammatory markers and the risk of sarcoidosis in Mendelian randomization (MR) analysis.The alternative text for this image may have been generated using AI.

Statistical analyses were conducted using a two-sided test. The analysis was based on European GWAS data including 7554 cases 1,367,006 and controls. The number of genetic instruments for inflammatory markers is presented in Supplementary Data 4. a Volcano plot of MR associations between 65 inflammatory markers and sarcoidosis. b Forest plot of 10 associations with P-value < 0.05. Data are presented as odds ratio +/− 95% confidence interval. c Reginal locus plot for interleukin 23 receptor (IL23R) and sarcoidosis. The associations in a and b were scaled to one standard deviation increase in genetically predicted markers. Source data are provided as a Source Data file. OR, odds ratio.

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