Fig. 8: PC inhibits the cytotoxic effect of CD8 T cells on MM cells by Sb9 in vivo. | Nature Communications

Fig. 8: PC inhibits the cytotoxic effect of CD8 T cells on MM cells by Sb9 in vivo.

From: Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma

Fig. 8: PC inhibits the cytotoxic effect of CD8 T cells on MM cells by Sb9 in vivo.The alternative text for this image may have been generated using AI.

a Representative image of tumors developing from bioluminescent WT or Sb9 KO KAS-6/1 and U266 cells in NOD-SCID mice co-injected with PC and WT or Sb9-overexpressed human CD8 T cells at days 9 and 25 postinjection of MM cells. b Quantification of the volume of xenograft tumors derived from WT or Sb9 KO KAS-6/1 and U266 cells in the presence and absence of PC and WT or Sb9-overexpressed human CD8 T cells in NOD-SCID mice. Mean± SD, n = 5 biologically independent mice. c Images of xenograft tumors derived from WT or Sb9 KO KAS-6/1 and U266 cells in the presence and absence of PC and WT or Sb9-overexpressed human CD8 T cells in NOD-SCID mice. Histograms indicate the quantification of the weight of tumors. Mean± SD, n = 5 biologically independent mice. Sb9 SerpinB9, MM multiple myeloma, WT wild type, PC phosphatidylcholine, KO knockout, OE overexpression. All statistical tests were two-sided. Statistical significance was assessed using one-way ANOVA followed by post-hoc Tukey’s test for (b) and (c). Adjustments were made for multiple comparisons. *P < 0.05; **P < 0.01. Source data are provided as a Source Data file.

Back to article page