Fig. 9: Activation of in vivo antitumor immune response by UCNP-Cro/FA upon irradiation. | Nature Communications

Fig. 9: Activation of in vivo antitumor immune response by UCNP-Cro/FA upon irradiation.

From: Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction

Fig. 9

A, B Flow cytometric analysis (A) and quantification (B) of M1-type TAMs (F4/F80+CD86+) and M2-type TAMs (F4/F80+CD206+) in tumors of mice after different treatments (n = 5 mice in each group). Statistical significance was calculated using an unpaired two-tailed t-test. C, D Flow cytometric analysis (D) and quantification (C) of matured DCs (CD11c+CD80+CD86+) in lymph nodes of mice after different treatments (n = 5 mice in each group). Statistical significance was calculated using an unpaired two-tailed t-test. E–G Flow cytometric analysis (G) and quantification of CD4+ T cells (CD3+CD4+) (E), CD8+ T cells (CD3+CD8+) (F) in spleens of mice after different treatments (n = 5 mice in each group). Statistical significance was calculated using an unpaired two-tailed t-test. H–J Flow cytometric analysis (H) and quantification of CD4+ T cells (CD3+CD4+) (I), CD8+ T cells (CD3+CD8+) (J) in tumors of mice after different treatments (n = 5 mice in each group). Statistical significance was calculated using an unpaired two-tailed t-test. K Mechanism of in vivo immune response activated by UCNP-Cro/FA upon irradiation. Created in BioRender. Luwen, Z. (2025) BioRender.com/m89r278. Groups 1, 2 and 3 represent Control, UCNP-Cro/FA and UCNP-Cro/FA + NIR, respectively. Error bars represent the mean ± SD. Source data are provided as a Source Data file.

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