Fig. 2: DNA methylation profiles of the cohort. | Nature Communications

Fig. 2: DNA methylation profiles of the cohort.

From: Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube

Fig. 2: DNA methylation profiles of the cohort.

a Region-centered binned averages show high DNA methylation levels for heterochromatin (top row), lack of methylation at transcriptional start sites (TSS; middle row), and nucleosome positioning around CTCF binding sites (bottom row). No difference in methylation by BRCA status at these features was detected. b Multiscale DNA methylation averages along chromosome 17 from 10 kb to 10 Mb showing no BRCA-associated differences in methylation at any of these scales. c Heatmap showing DNA methylation levels at loci known to be hypermethylated in STIC or HGSC (rows) for samples of different origins (columns). Regardless of study origin and BRCA status, benign FTs do not show gain of methylation at these loci.

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