Fig. 3: COVA1-27 uptake in convalescent animals. | Nature Communications

Fig. 3: COVA1-27 uptake in convalescent animals.

From: Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates

Fig. 3: COVA1-27 uptake in convalescent animals.The alternative text for this image may have been generated using AI.

a Representative PET/CT fusion axial view of the sinus of one convalescent animal (CM2) with the corresponding quantification (b, c) of the mean and maximum [89Zr]COVA1-27-DFO PET signal in the brain of all animals normalized to that at D1post injection. d Representative CT lung lesion, indicated by the yellow circle, and its associated PET signal (e), indicated by the white circle, on D7pi. f Corresponding quantification of the maximum PET signal in the lesional (gray background, n = 6 areas) and non-lesional areas (square symbols, white background, n = 6 areas) on D7pi compared to that for naïve animals (black symbols (n = 7 areas). g Axial view of the [89Zr]COVA1-27-DFO PET signal in the brain, indicated by the white arrows, at D3pi. Corresponding quantification (h, i) of the maximum and mean [89Zr]COVA1-27-DFO PET signal in the brains of all animals normalized against that on D1pi. Mann Whitney two-sided t-test, *: p = 0.014, **:p = 0.008. Convalescent + COVA animals are indicated in green and the mock + COVA animals in black. Data are presented as individual values and the associated mean and SD. Source data are provided as a Source data file.

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