Fig. 4: SARS-CoV-2 RNA titers in the nasopharyngeal and tracheal compartments.

Evaluation of the SARS-CoV-2 genomic RNA (gRNA) titers (Log10 copies/mL) over two weeks in the nasopharynx (a) and trachea (b). The individual follow-up is represented by the thin lines and the average (mean) of each group by the bold lines. Horizontal dotted line: limit of quantification (LoQ)/limit of detection (LoD), vertical dotted line: euthanasia (n = 2) during the acute phase of the infection. SARS-CoV-2 gRNA titers (log10 copies/mL) showing the individual peak values for each group in the nasopharynx (c) and trachea (d). Area under the curve (AUC) calculated for each group in the nasopharynx (e) and trachea (f). The Mock + COVA group is indicated in black (n = 3 animals), the exposed + COVA group in turquoise (n = 4 animals), and the exposed + IgG group in pink (n = 2 animals). c–f Data are presented as individual values (circles) with the mean and standard deviation. Source data are provided as a Source data file.