Fig. 5: COVA1-27 uptake in the nasal cavity. | Nature Communications

Fig. 5: COVA1-27 uptake in the nasal cavity.

From: Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates

Fig. 5

a Representative image of CT-detected opacity in the left sinus on day 3 post-exposure (dpe) indicated by the yellow arrows. b Corresponding PET signal in the left sinus indicated by the white arrows, color scale: 0–3 SUV. c 3D representation of both CT opacity (in yellow) and the PET signal (in orange) in the left sinus of the nasal cavity (in green) at 3 dpe. d Longitudinal evaluation of the PET signal (SUVmax) normalized to that at D0 in the nasal cavity. e Evolution from 2 (hollow symbol) to 3 dpe (filled symbol) of the radioactivity in the nasopharyngeal swabs correlated with the SARS-CoV-2 gRNA titres in the same sample. f Percentage of radioactivity change between 2 and 3 dpe in the nasopharyngeal compartment per group, data are represented with individual values and associated mean values and SD. The exposed + COVA group is indicated in turquoise (circles and squares), the mock + COVA group in black (triangles), and the exposed + IgG group in pink (circles and squares), n = 2 animals per group. Source data are provided as a Source data file.

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