Fig. 7: COVA1-27 uptake in the lungs. | Nature Communications

Fig. 7: COVA1-27 uptake in the lungs.

From: Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates

Fig. 7

a, c Representative ground-glass opacity CT lung lesions indicated by the white arrow and (b, d) the associated PET signal (arrows) at 7 dpe. e CT score grading of lung lesion severity at 2 dpe. Data are presented as individual values with the mean and standard deviation (n = 6 animals in exposed + COVA group, n = 2 animals in exposed + IgG group, n = 3 animals in mock + COVA group). f Quantification of the maximum PET signal in the lesional (squares, gray background) and non-lesional areas (circles, white background) of the lungs of animals (n = 12 ROI in exposed + COVA group, n = 9 ROI in exposed + IgG group and n = 7 ROI for mock + COVA group). Data are presented as individual ROI values with the mean and standard deviation. Mann Whitney two-sided t-tests, *p < 0.05, **p < 0.01, ***p < 0.001. The exposed + COVA group is indicated in turquoise, the exposed + IgG group in pink and, the mock + COVA group in black. Source data are provided as a Source data file.

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