Fig. 8: Illustration of NCT usage to explore network correspondence between user-defined input data and multiple atlases: HCP Example 2.

In this example, we explore the overlap between the HCP social task contrast (theory of mind vs. random) and 8 atlases. The user provides the input data together with a config file specifying the name, data space, data type, and the threshold which is used to threshold the input data. The user also provides an atlas list indicating which atlases to include. The NCT thresholds the data based on the config file and projects the atlases in the atlas list to the input data space. The NCT computes the Dice overlap between the thresholded data and all networks from atlases in the list. The NCT also performs spin tests to test whether the thresholded input data and networks significantly overlap. The NCT reports the network correspondence summary using a “Network Clock” plot (middle), a “Network Radar” plot (top right), and a summary table showing the exact Dice coefficients and p-values for all atlases (see Supplementary Table 4). The “Network Clock” provides a visual comparison of Dice overlap across networks from different atlases. Different colors represent different atlases. The lollipop bars represent the Dice overlap coefficients. Networks significantly overlapping with the thresholded input data (p < 0.05) are indicated by the network names. Larger font sizes represent larger Dice coefficients. The “Network Radar” shows the Dice overlap across networks within each atlas. Networks significantly overlapping with the thresholded input data (p < 0.05) are indicated by “*” in the “Network Radar”. Dors dorsal, attn attention, post posterior, multi multimodal, temp temporal, par parietal, med medial, front frontal, ven ventral occ occipital, lat lateral, vis visual, cing cingulo, operc opercular, ant anterior, MTL medial temporal lobe, SM somatomotor.