Fig. 3: Phosphate binding by XPR1.
From: Structure and function of human XPR1 in phosphate export
a Two potential phosphate binding sites of XPR1 are marked by squares. The scaffold domain (TM1-TM4) and core domain (TM5-TM10) are colored in green and cyan, respectively. b A zoomed-in view of the external phosphate binding site. c Surface electrostatic potential of the external binding site. d Transport activity of XPR1 variants with point mutations at the external site. P values from the two-tailed t-test are indicated on the bar chart. e, f Zoomed-in views of the central phosphate binding site from the cytosol (e) and the side (f). g Transport activity of XPR1 variants with point mutations at the central site. The data points are the mean ± s.e.m. (n = 6 independent experiments). P values from the two-tailed t-test are indicated on the bar chart.
