Fig. 4: Extracelluar gate of XPR1.
From: Structure and function of human XPR1 in phosphate export
a Ion conduction pathway of HsXPR1 calculated by the Hole program. b The interactions between TM9 and TM5-7. c Ion conduction pathway of XPR1open (PDB: 8X5E) calculated by Hole program. d Pore radii of HsXPR1 and XPR1open. W573 and the central Pi binding site are indicated by black arrows. The pore radii of HsXPR1 and XPR1open are shown in cyan and salmon, respectively. e, f Structural comparison between HsXPR1 and XPR1open (PDB: 8X5E). Y518, R570, and W573 are shown in stick. For clarity, TM8s are not shown in (e).
