Fig. 3: Interaction between AftB and bound 2F-FPA.
From: Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan
a Structure of AftB complexed with 2F-FPA shown in ribbon. The TM domain of AftB is colored in rainbow as in Fig. 1d, while the PD is colored in white. 2F-FPA is shown in sticks and colored in magenta. Cryo-EM density of 2F-FPA colored with semi-semitransparent magenta. WebLogo plots102 show the amino acids interacting with 2F-FPA. b Close-up view of the interaction between AftB and 2F-FPA. Polar contacts are indicated as black dashed lines. Residues involved in the interaction are shown as sticks. The distance between the catalytic residue D62 and C1 of 2F-FPA is indicated with blue dashed lines. c, d Electrostatic surface depiction of the AftB-2F-FPA complex, a partial cross-sectional perspective is applied to highlight the active site cavity with the bound donor substrate-analog 2F-FPA.
