Fig. 5: LLPS performance of Martini3-IDP.

A Density profiles along the Z-axis, together with a snapshot of the last frame of the trajectory, for a variety of homotypic and heterotypic systems. Residues are color-coded white for apolar, green for uncharged polar, red for anionic and blue for cationic. Density profiles were averaged over the whole trajectory after discarding the initial equilibrium phase, and centered at the center-of-mass of the condensate (Z = 0). B Snapshots and radial bead density profiles of multiphase condensates. Orange chains represent LAF1 and residue type specific chains represent Asyn and FUSLCD (Residues are color-coded white for apolar, green for uncharged polar, red for anionic and blue for cationic). Density profiles were obtained with respect to the center-of-geometry of the condensate, orange lines represent LAF1, green lines represent Asyn or FUSLCD. FUSLCD, A1LCD,TIA1LCD represent the LCD of RNA binding proteins hnRNPA1, protein Fused in Sarcoma and TIA-1, GY23 represents GY23 peptide, mfp-3S represents mussel foot protein mfp-3S. ProA+H1 represents the mixture of Histone H1 and its nuclear chaperone Prothymosin-a. LAF1 represents the N-terminal intrinsically disordered RGG region of ATP-dependent RNA helicase LAF-1.