Fig. 7: Combining RNA-seq measurements from clinically accessible tissues with AbExp further improves the prediction performance.
From: Aberrant gene expression prediction across human tissues
a Left: Distribution per predictor (rows) of average precision (AUPRC) across 26 tissue types excluding skin tissues (Methods). Center line, median; box limits, first and third quartiles; whiskers span all data within 1.5 interquartile ranges of the lower and upper quartiles. P-values were obtained using the paired two-sided Wilcoxon test. The “Gene expression (CAT)” predictor ranks genes according to their OUTRIDER z-score in fibroblasts RNA-seq data. Right: Precision-recall curve aggregated across the same GTEx tissues as in the left panel. LOFTEE as a binary predictor is shown as a single point. b as in (a) using Whole blood as CAT and all other tissues as non-CAT.
