Fig. 5: Accuracy of parameter inference using approximate Bayesian computation sequential Monte Carlo (ABC SMC) on simulated data.
From: Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability
a Overview of ABC. The dashed arrow indicates that the posterior distribution contributes to the prior distribution in ABC SMC. b The proportion of differences between estimated and real double-strand break (DSB) rate per cycle. c The proportion of differences between estimated and real fraction of unrepaired DSBs per cycle. d The proportion of differences between estimated and real probability of whole genome doubling (WGD) per cell. e The proportion of differences between estimated and real mean number of chromosome fusions per cycle. f The proportion of differences between estimated and real number of extrachromosomal circular DNAs (ecDNAs) per cell. The box plots show the median (centre), 1st (lower hinge), and 3rd (upper hinge) quartiles of the data; the whiskers extend to 1.5 times of the interquartile range (distance between the 1st and 3rd quartiles); data beyond the interquartile range are plotted individually. There are 10 data points for each box plot, which represent the posterior means of 10 runs under the same parameter setting. Source data are provided as a Source Data file.
