Fig. 7: Results of fitting the cell-cycle model to bulk whole-genome sequencing data using approximate Bayesian computation sequential Monte Carlo (ABC SMC).
From: Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability
The five groups of violin plots show the posterior distributions of three inferred parameters and the posterior predictive distributions of the unobserved numbers of chromosome fusions and extrachromosomal circular DNAs (ecDNAs) for 82 well-fit bulk whole-genome sequencing datasets. The names of datasets without whole genome doubling (WGD) are shown in grey. The red bar in the last two groups of violin plots indicates the number of detected breakage-fusion-bridges (BFBs) or ecDNAs. The orange bar in the last group of violin plots indicates the number of ecDNAs from database that overlap with structural variants (SVs). The numbers above the two bottom groups of violin plots represent the numbers of detected chromothripsis. The box plots show the median (centre), 1st (lower hinge), and 3rd (upper hinge) quartiles of the data; the whiskers extend to 1.5 times of the interquartile range (distance between the 1st and 3rd quartiles); data beyond the interquartile range are plotted individually. Each box plot contains 500 data points, which represent the posterior samples. Source data are provided as a Source Data file.
