Fig. 8: Relationships between inferred values and known numbers of events.
From: Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability
a The relationship between inferred posterior means of extrachromosomal circular DNAs (ecDNAs) and numbers of ecDNAs from database that overlap with structural variants (SVs) for 19 well-fit single-cell whole-genome sequencing datasets. b The relationship between inferred posterior means of ecDNAs and numbers of SV-overlapping ecDNAs from database for 82 well-fit bulk whole-genome sequencing datasets. c The relationship between inferred posterior means of ecDNAs and known numbers of chromothripsis for 82 well-fit bulk whole-genome sequencing datasets. d The relationship between inferred posterior means of chromosome fusions and known numbers of chromothripsis for 82 well-fit bulk whole-genome sequencing datasets. e The relationship between inferred posterior means and known mean numbers of ecDNAs for 82 well-fit bulk whole-genome sequencing datasets. f The relationship between inferred posterior means and known numbers of breakage-fusion-bridges (BFBs) or chromosome fusions for 82 well-fit bulk whole-genome sequencing datasets. In (a, b) the blue lines were derived from robust linear regressions. The Spearman correlation coefficient and corresponding two-sided p-value are shown for each plot. Jittering with both height and width set to 0.1 are applied for better visualisation of overlapping data points. Source data are provided as a Source Data file.
