Table 1 Selected condition optimizations


Entry^a	Variations from standard conditions	Yield (%)	ee (%)^e
1	None	76^b	98
2	L1 instead of L4	8^c	/
3	L2 instead of L4	58^c	40
4	L3 instead of L4	74^c	9
5	L5 instead of L4	66^c	60
6	L6 instead of L4	94^c	-46
7	w/o CoCl₂	NR^d	/
8	w/o Co[(S,S)-Ph-BPE]Cl₂	NR^d	/
9	w/o 3DPA2FBN	NR^d	/
10	w/o Et₃N	NR^d	/
11	w/o HE	16^d	/
12	no light	NR^d	/

^aUnless otherwise noted: 1a (0.15 mmol, 1.0 equiv), 2a (0.45 mmol, 3.0 equiv), Co[(S,S)-Ph-BPE]Cl₂ (10 mol%), 3DPA2FBN (3 mol%), Et₃N (0.075 mmol, 0.5 equiv), HE (0.15 mmol, 1.0 equiv) in CH₃CN (0.5 mL) under 450 nm blue LEDs for 48 h under N₂.
^bIsolated yield.
^c2a (0.30 mmol, 2.0 equiv), CoCl₂ (10 mol%), Ligand (10 mol%), Et₃N (0.15 mmol, 1.0 equiv), HE (0.15 mmol, 1.0 equiv) in CH₃CN (2.0 mL), and the yields were determined by GC-FID analysis using dodecane as the internal standard.
^dYields were determined by crude ¹H NMR using 1,1,2,2-tetrachloroethane as internal standard.
^eDetermined by chiral HPLC.

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