Fig. 5: Stimulation of Piezo2⁺ mechanical nociception promotes implant osseointegration.

a–d micro-CT images and quantitative analysis of bone tissue surrounding implants were conducted in Piezo2::ChR2 mice across Non_OS, OS and ES groups, at 2 and 4 week post-implantation, scale bar: 100 μm. Data are presented as mean ± SEM (n  =  5 biologically independent experiments). P-values were calculated using one-way ANOVA with Tukey’s multiple comparisons test. (BV/TV: bone volume/total volume, Tb.Th: trabecular thickness, Tb.N: number of trabeculae, Tb.Sp: trabecular spacing, BMD of BV: bone mineral density of bone volume, BIC%: bone-implant contact percentage). Source data are provided as a Source Data file.