Fig. 6: OS of Piezo2⁺ mechanical nociception promotes implant osseointegration.

a–d Methylene blue-acid fuchsin staining images and semi-quantitative analysis of bone tissue containing implants in Piezo2::ChR2 mice, with and without OS and ES, at 2 and 4 week post-implantation, scale bar: 10×: 100 μm, 40×: 100 μm. Data are presented as mean ± SEM (n  =  5 biologically independent experiments). P-values were calculated using one-way ANOVA with Tukey’s multiple comparisons test. e–f ELISA detection of CGRP expression levels in bone tissue surrounding implants in Piezo2::ChR2 mice, with and without OS and ES, at 2 and 4 week post-implantation. Data are presented as mean ± SEM (n  =  5 biologically independent experiments). P-values were calculated using one-way ANOVA with Tukey’s multiple comparisons test. Source data are provided as a Source Data file.