Fig. 7: Structural mimicry of UM171 and cancer mutant KBTBD4R313PRR. | Nature Communications

Fig. 7: Structural mimicry of UM171 and cancer mutant KBTBD4R313PRR.

From: Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Fig. 7: Structural mimicry of UM171 and cancer mutant KBTBD4R313PRR.The alternative text for this image may have been generated using AI.

Superposition of UM171 and KBTBD4R313PRR at site 1 (a) or site 2 (b). UM171 and key interacting residues are shown as sticks. Subunits are coloured as following: in the UM171 model, KBTBD4WT chains in blue and light blue, UM171 in yellow and HDAC2 in pink; in the KBTBD4R313PRR model, KBTBD4R313PRR in purple and light purple and HDAC2 in green.

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