Table 1 Metal analysis by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

From: Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair

MUTYH

[4Fe-4S] load

Zn load

WT (MBP free)

5.1 ± 0.1

1.2 ± 0.1

WT

4.4 ± 0.1

0.2 ± 0.1

W103C

0.0

0.0

W103R

0.0

0.0

N238S

4.1 ± 0.2

0.3 ± 0.1

R241Q

4.4 ± 0.1

0.1 ± 0.02

R241W

0.0

0.0

R245H

0.0

0.0

R245C

0.0

0.0

V246F

3.9 ± 0.5

0.2 ± 0.1

C290W

0.0

0.0

P295L

0.0

0.0

C306W

0.0

0.0

R309C

4.9 ± 0.3

0.2 ± 0.01

  1. Values equal to 0 mean that the protein sample had Zn and Fe content equal to the blank. Source data are provided as a Source Data file.
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