Fig. 2: Site-specific pattern of DNA copy number aberrations in CRC metastases based on the CRCTropism cohort.
From: Cytogenetic signatures favoring metastatic organotropism in colorectal cancer
a Organotropic map presenting CIs with site-specific enrichment (n = 191). All p-values were obtained by two-sided Fisher exact tests followed by Benjamini-Hochberg adjustment for multiple comparison (legend). The size of the bubbles encodes the frequency a given CI was observed in the cohort (legend). b Doughnut plots showing the fraction of metastases (n = 191) that harbor selected organotropic CIs (see legend for the assignment of secondary organs: li, liver; lu, lung; br, brain; chr., chromosomal arm; see also Supplementary Fig. 5 for a full representation of all organotropic CIs). The frequency of occurrence is color-encoded according to the legend shown on the right. Two-sided Fisher exact tests with Benjamini-Hochberg adjustment for multiple comparison were used (*, padjust < 0.05; **, padjust < 0.01, and ***, padjust < 0.001). (1) padjust = 3.80 × 10−2; (2) padjust = 1.14 × 10−2; (3) padjust = 2.48 × 10−2; (4) padjust = 3.80 × 10−2; (5) padjust = 4.10 × 10−2; (6) padjust = 7.80 × 10−3; (7) padjust = 3.80 × 10−2; (8) padjust = 4.85 × 10−3; (9) padjust = 4.22 × 10−3; (10) padjust = 3.08 × 10−7. c Graphical summary of autosomal organotropic CIs with arbitrary intra-organ sites of lesions. CIs observed in more than 15% of the respective metastases are highlighted in bold. Source data are provided as a Source Data file.
