Fig. 3: PVTX-405 rapidly degrades IKZF2 with high potency in a CRBN-dependent manner. | Nature Communications

Fig. 3: PVTX-405 rapidly degrades IKZF2 with high potency in a CRBN-dependent manner.

From: Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy

Fig. 3

a FACS analysis of IKZF2 degradation in Jurkat cells after PVTX-405 treatment. Data presented as mean ± SD, with n = 2 biological replicates for each concentration. b Kinetics of IKZF2 degradation by PVTX-405 and DKY709 in HEK293 IKZF2 HiBiT cell line. Data presented as mean ± SD, with n = 2 biological replicates for each concentration. c Western blotting analysis shows that CRISPR/Cas9 mediated KO of CRBN in Jurkat cells completely abrogates IKZF2 degradation by PVTX-405. Representative blots from two independent experiments. Source data are provided as a Source Data file.

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