Table 1 Characteristics of female survivors of childhood cancer who developed subsequent breast cancers (N = 431)
Characteristic | N | % or median (IQR) |
|---|---|---|
Primary cancer diagnosis | ||
Hodgkin lymphoma | 251 | 57.9 |
Leukemia | ||
Lymphoblastic leukemia | 30 | 7.5 |
Acute myeloid leukemia | 14 | 3.2 |
Other leukemia | 3 | 0.7 |
Sarcoma | ||
Soft tissue sarcoma | 26 | 6.0 |
Osteosarcoma | 34 | 7.8 |
Ewings sarcoma | 23 | 5.3 |
Other bone tumor | 1 | 0.2 |
Kidney tumor | 19 | 4.4 |
Non-Hodgkin lymphoma | 18 | 4.2 |
Neuroblastoma | 5 | 1.2 |
Central nervous system tumor | ||
Astrocytoma | 6 | 1.4 |
Medulloblastoma | 1 | 0.2 |
Age at childhood cancer diagnosis (years) | 431 | 15 (13-17) |
Race | ||
White | 412 | 95.6 |
Non-White | 19 | 4.4 |
Childhood cancer treatmenta | ||
Treated with chest radiotherapy | 279 | 68.6 |
Received anthracyclines | 174 | 42.7 |
Other late chronic health conditions | ||
Major cardiovascular event before breast cancer | 49 | 11.3 |
Major cardiovascular event after breast cancer | 35 | 8.1 |
Subsequent malignancy before breast cancer | 22 | 5.1 |
Subsequent malignancy after breast cancer | 36 | 8.3 |
Age at first breast cancer diagnosis (years) | 431 | 40 (35-44) |
Years between primary and breast cancer diagnosis | 431 | 24 (19-29) |
Breast cancer treatment era | ||
Before 2000 | 115 | 26.5 |
2000-2009 | 186 | 42.9 |
2010-2016 | 130 | 30.6 |
Subsequent breast cancer stageb | ||
0 | 101 | 26.3 |
I | 120 | 31.3 |
II | 112 | 29.9 |
III | 34 | 8.9 |
IV | 14 | 3.7 |
Breast cancer histologyb | ||
DCIS/LCIS only | 101 | 23.5 |
Invasive | 326 | 76.5 |
Other breast tumor characteristicsc | ||
Progesterone receptor positive | 215 | 66.9 |
Estrogen receptor positive | 266 | 77.7 |
HER2 positive | 64 | 25.8 |
Vital status | ||
Deceased | 164 | 37.8 |
