Fig. 6: Both gut microbiota remodeling by torularhodin and A. muciniphila reduce Cer levels by inhibiting the colonic HIF-2α pathway. | Nature Communications

Fig. 6: Both gut microbiota remodeling by torularhodin and A. muciniphila reduce Cer levels by inhibiting the colonic HIF-2α pathway.

From: The carotenoid torularhodin alleviates NAFLD by promoting Akkermanisa muniniphila-mediated adenosylcobalamin metabolism

Fig. 6: Both gut microbiota remodeling by torularhodin and A. muciniphila reduce Cer levels by inhibiting the colonic HIF-2α pathway.The alternative text for this image may have been generated using AI.

A–C Levels of Cer (Glc-Cer, Cer, SM) in germ-free mice serum, liver, and feces (n = 6). D–F Levels of Cer (Glc-Cer, Cer, SM) in A. muciniphila transplantation mice serum, liver, and feces (n = 8). G Blots and grayscale analysis of MUC2, HIF-2α, Occludin and Neu3 proteins in germ-free mice colon (n = 6). H Blots and grayscale analysis of MUC2, HIF-2α, Occludin, and Neu3 proteins in A. muciniphila transplantation mice colon (n = 6). Data are expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, compared with the Mod or GF Mod group, and p-value was calculated using Dunnet’s post hoc test in one-way ANOVA. The small icons in (A–H) are created in BioRender. Liu, C. (2025) https://BioRender.com/k07f052.

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