Fig. 7: Adenosylcobalamin reduces Cer levels by inhibiting the HIF-2α pathway, ultimately mitigating NAFLD in mice. | Nature Communications

Fig. 7: Adenosylcobalamin reduces Cer levels by inhibiting the HIF-2α pathway, ultimately mitigating NAFLD in mice.

From: The carotenoid torularhodin alleviates NAFLD by promoting Akkermanisa muniniphila-mediated adenosylcobalamin metabolism

Fig. 7: Adenosylcobalamin reduces Cer levels by inhibiting the HIF-2α pathway, ultimately mitigating NAFLD in mice.The alternative text for this image may have been generated using AI.

A Flowchart of the adenosylcobalamin compensation experiment. B Trend of body weight in mice (n = 8). C Weight gain of mice at the 8th week (n = 8). D–H Levels of TC, TG, LDL-C, AST and ALT in mice serum (n = 8). I H&E and Oil Red O sections of mice liver (200×) (n  =  3). J–L Levels of Cer (Glc-Cer, Cer, SM) in mice serum, liver, and feces (n = 8). M Blots and grayscale analysis of HIF-2α and Neu3 proteins in mice colon (n = 6). Data are expressed as mean ± SD, *p  <  0.05, **p  <  0.01, ***p  <  0.001, compared with the Mod group, and p-value was calculated using Dunnet’s post hoc test in one-way ANOVA. A created in BioRender. Liu, C. (2025) https://BioRender.com/v54i969. The small icons in J–M are created in BioRender. Liu, C. (2025) https://BioRender.com/k07f052.

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