Fig. 2: Developmental patterns of MRI-derived cortical morphology and microstructure.
a regions in atlas used to derive domain-specific networks81 overlaid on a representative participant; b developmental patterns of cortical morphology and microstructure averaged across the cortical ribbon; c network-wide patterns of microstructure and morphology, indicating age-related increases in neurite fraction and reductions in cortical thickness, apparent soma radius, soma fraction and extracellular fraction; d demonstration of high repeatability of SANDI measures in six adults scanned over 5 time-points within two weeks; e spatial representation of networks. Significant age relationships determined with a linear regression (p < 0.005) are annotated (*) and exact p values are reported in Table S2. Curves in (b, c) represented as mean trajectory with 95% confidence interval bounds. Abbreviations: CTh cortical thickness, in mm, fextracellular extracellular signal fraction, fneurite neurite signal fraction, fsoma soma signal fraction, GM grey matter, ICC intra-class coefficient, Rsoma apparent soma radius, in µm. Colour coding in (a, e) corresponds to regions in (c, d). Source data for (d) are provided as a Source Data file.
