Fig. 1: COSMIC Tier 1 genes significantly mutated in sarcomas. | Nature Communications

Fig. 1: COSMIC Tier 1 genes significantly mutated in sarcomas.

From: Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes

Fig. 1: COSMIC Tier 1 genes significantly mutated in sarcomas.The alternative text for this image may have been generated using AI.

Top 10 most significantly mutated genes from robust regression in each histology subtype intersected with the COSMIC Tier 1 gene list (A) shows the high mutation frequency of TP53 across all histology subtypes and histology-specific mutations like KIT. Tumor mutation burden of all non-silent mutations in sarcomas compared to TCGA PanCancer Study (B) show similar tumor mutation burden in ORIEN compared to TCGA SARC.

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