Fig. 1: Ffar4-/- mice show decreased glucose-stimulated insulin secretion. | Nature Communications

Fig. 1: Ffar4-/- mice show decreased glucose-stimulated insulin secretion.

From: FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

Fig. 1: Ffar4-/- mice show decreased glucose-stimulated insulin secretion.

a Body weight of wild-type (Ffar4+/+, n = 11) and FFAR4 knockout (Ffar4-/-, n = 9) mice fed with normal-chow diet. b Blood glucose levels at the indicated time points after glucose injection in Ffar4+/+ (n = 11) and Ffar4-/- (n = 10) mice. c Glucose infusion rate (GIR) in hyperinsulinemic-euglycemic clamp experiments in Ffar4+/+ and Ffar4-/- mice (n = 10). The bar diagram shows the steady-state GIR during the last 30 mins. d Plasma insulin levels at the indicated time points after glucose injection in Ffar4+/+ (n = 10) and Ffar4-/- (n = 9) mice. e Insulin secretion from islets isolated from Ffar4+/+ and Ffar4-/- mice (n = 6) at different glucose levels. Results were normalized to islet protein levels. f Size distribution of the islets isolated from Ffar4+/+ and Ffar4-/- mice (n = 3). Shown are mean values ± SEM; P-values are given in the figure; n.s.: not significant (Bonferroni’s two-way ANOVA test (a, b, c (left panel), d–f), unpaired non-parametric two-tailed Mann-Whitney U test (c (right panel)). Source data are provided as a Source Data file.

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