Fig. 6: FFAR4-mediated IL-6-dependent insulin secretion is compromised in type-2 diabetic patients. | Nature Communications

Fig. 6: FFAR4-mediated IL-6-dependent insulin secretion is compromised in type-2 diabetic patients.

From: FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

Fig. 6: FFAR4-mediated IL-6-dependent insulin secretion is compromised in type-2 diabetic patients.

a Insulin secretion from islets isolated from pancreata of healthy (n = 9) and type-2 diabetic (n = 9) donors in the presence of 5.6 or 16.7 mM glucose after incubation without or with 20 µM TUG-891. Results were normalized to islet protein levels. b IL-6 release from islets isolated from pancreata of healthy (n = 9) and type-2 diabetic (n = 9) donors. Islets were treated without or with 20 µM TUG-891 for 48 h, and the IL-6 levels in the supernatant were determined by ELISA. Results were normalized to islet protein levels. c Insulin secretion from islets isolated from pancreata of healthy (n = 9) and type-2 diabetic (n = 9) donors in the presence of 5.6 or 16.7 mM glucose after incubation with or without 10 µM IL-6 for 24 hrs. Results were normalized to islet protein levels. Shown are mean values ± SEM; P-values are given in the figure; n.s.: not significant (Bonferroni’s two-way ANOVA test (a–c)). Source data are provided as a Source Data file.

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