Table 1 Hydrogenation of 1-acetyl-3-methylpiperidine (1) using various catalytic systems and conditions

From: Low pressure amide hydrogenation enabled by magnetocatalysis

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Heating

#

Catalyst

PH2 (bar)a

μ0H (mT)

TReactor (°C)

Conv. (%)

Y1a (%)

Conventional heating

1b

Pt/Al2O3

50

200

43

43

 

2

Pt/Al2O3

3

200

2

2

 

3

ICNPs@Pt/Al2O3

3

200

7

7

 

4b

ICNPs@Pt/Al2O3

3

300

60

60c

Magnetic induction heating

5

ICNPs@Pt/Al2O3

3

36

110d

7

7

 

6

ICNPs@Pt/Al2O3

3

54

130d

57

57

 

7

ICNPs@Pt/Al2O3

3

63

147d

78

78

 

8

ICNPs@Pt/Al2O3

3

72

156d

>99

>99

 

9e

ICNPs@Pt/Al2O3

1

72

156d

>99

>99

 

10

ICNPs@Pt/Al2O3

3

80

158d

>99

>99

 

11f

ICNPs@Pt/Al2O3

3

72

174d

>99

>99

 

12g

ICNPs@Pt/Al2O3

3

72

31

31

 

13h

ICNPs@Pt/Al2O3

3

72

11

11

 

14

Pt/Al2O3

3

72

r.t.

0

0

 

15

ICNPs

3

72

37

37

 

16

ICNPs + Pt/Al2O3

3

72

55

55

  1. Reaction conditions: 1 (12.9 mg, 0.10 mmol), catalyst, decalin (0.5 mL), H2 (3 bar), 4 h in a Fisher-Porter bottle. Product yields determined by GC-FID using tetradecane as the internal standard. μ0Hmax (mT) magnetic field amplitude. T temperature, Conv. conversion, Y1a yield of 1a.
  2. aPressure at room temperature. Increase of pressure at reaction temperature below 0.5 bar for reactions using magnetic induction heating.
  3. bThe reaction was performed in an autoclave (the setup illustrated in supporting information).
  4. cMass balance not closed.
  5. dDetermined using an infrared camera.
  6. e40 h.
  7. f40 wt% of ICNPs.
  8. g16 wt% of ICNPs.
  9. h7 wt% of ICNPs.