Table 1 Hydrogenation of 1-acetyl-3-methylpiperidine (1) using various catalytic systems and conditions
From: Low pressure amide hydrogenation enabled by magnetocatalysis
Heating | # | Catalyst | PH2 (bar)a | μ0H (mT) | TReactor (°C) | Conv. (%) | Y1a (%) |
|---|---|---|---|---|---|---|---|
Conventional heating | 1b | Pt/Al2O3 | 50 | – | 200 | 43 | 43 |
2 | Pt/Al2O3 | 3 | – | 200 | 2 | 2 | |
3 | ICNPs@Pt/Al2O3 | 3 | – | 200 | 7 | 7 | |
4b | ICNPs@Pt/Al2O3 | 3 | – | 300 | 60 | 60c | |
Magnetic induction heating | 5 | ICNPs@Pt/Al2O3 | 3 | 36 | 110d | 7 | 7 |
6 | ICNPs@Pt/Al2O3 | 3 | 54 | 130d | 57 | 57 | |
7 | ICNPs@Pt/Al2O3 | 3 | 63 | 147d | 78 | 78 | |
8 | ICNPs@Pt/Al2O3 | 3 | 72 | 156d | >99 | >99 | |
9e | ICNPs@Pt/Al2O3 | 1 | 72 | 156d | >99 | >99 | |
10 | ICNPs@Pt/Al2O3 | 3 | 80 | 158d | >99 | >99 | |
11f | ICNPs@Pt/Al2O3 | 3 | 72 | 174d | >99 | >99 | |
12g | ICNPs@Pt/Al2O3 | 3 | 72 | – | 31 | 31 | |
13h | ICNPs@Pt/Al2O3 | 3 | 72 | – | 11 | 11 | |
14 | Pt/Al2O3 | 3 | 72 | r.t. | 0 | 0 | |
15 | ICNPs | 3 | 72 | – | 37 | 37 | |
16 | ICNPs + Pt/Al2O3 | 3 | 72 | – | 55 | 55 | |
