Fig. 7: SCM-08 is a highly selective CYP3A4 inhibitor that does not target other CYPs. | Nature Communications

Fig. 7: SCM-08 is a highly selective CYP3A4 inhibitor that does not target other CYPs.

From: Decoding the selective chemical modulation of CYP3A4

Fig. 7

Dose–response curves showing concentration-dependent inhibition of a panel of CYPs as determined using the P450-Glo and the Vivid P450 assays. Percentage inhibition data were normalized against DMSO controls (as 0% inhibition) and 30 µM control inhibitors (as 100% inhibition). The reported numerical values are the means and standard deviations of the IC50 values calculated from triplicate experiments (n = 3). Source data are provided as a Source Data file.

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