Fig. 2: in silico analyses of TRIM family proteins highlights notable structural differences in the RING domain. | Nature Communications

Fig. 2: in silico analyses of TRIM family proteins highlights notable structural differences in the RING domain.

From: Identification of RING E3 pseudoligases in the TRIM protein family

Fig. 2

a Schematic representations of binding interfaces between TRIM RING homodimers (left) and between TRIM RING dimers and the E2~ubiquitin conjugate (right). Created in BioRender. Dudley, J. (2025) https://BioRender.com/v35y632. b Aligned AlphaFold2 structural predictions of the RING domains of class IV TRIMs (N-terminal Met to end of α3 helix, or with a sequence of a corresponding length where no α3 helix is predicted), with divergent structural features of TRIMs 6, 15 and 51 highlighted in an enhanced zoom of the core RING domain. c AlphaFold2 predictions of core RING domains of TRIMs 6, 15 and 51.

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