Fig. 6: Alterations in the diversity and composition of gut-associated vegetable viruses in people with metabolic and inflammatory disorders.

a The comparisons of gut-associated vOTU composition, Shannon index, and total FPKM between healthy and disease groups are shown for obesity, ulcerative colitis (UC), colorectal cancer, alcoholic liver disease (ALD), and type 2 diabetes (T2D) with/without diabetic nephropathy (DN). The analyses were performed using principal coordinate analysis or distance-based redundancy analysis with Bray-Curtis dissimilarity. The best-fit model was constrained to cancer progression and fecal occult blood test (FOBT). Box plots include a center line (median), box limits (upper and lower quartiles), and whiskers (minimum and maximum values). b vOTUs significantly enriched or depleted in either healthy or disease group are shown for six datasets. All data are presented as mean ± S.D. Statistical significance was determined by one-tailed Mann-Whitney test. Symbol: *P-value < 0.05; **P-value < 0.01; and ***P-value < 0.001. Source data are provided as a Source Data file.