Fig. 5: Differential effects of H3.1K27M expression in DNA repair mutants.
From: H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability
Genotypes of T1 transgenic plants resulting from transformation of H3.1 WT and H3.1K27M into rad51 heterozygous (rad51 [+/-]) (A) and mre11 heterozygous (mre11 [+/-]) (B) T0 plants. C, D Chromosomal view (Chr 5) of DNA-seq reads. The pericentromeric region is highlighted in gray. E Model depicting how H3.1K27M expression leads to genomic instability by increasing the levels of H3.1K27me0, which causes misregulation of TSK. Created in BioRender. Jacob, Y. (2025) https://BioRender.com/l39x793. Source data are provided as a Source Data file.
