Fig. 7: Assessment of the therapeutic effect of GMOC in a post-operation IDD model in rabbits.
From: An enzyme-proof glycan glue for extracellular matrix to ameliorate intervertebral disc degeneration
A Schematic diagram of GMOC treatment in rabbit IDD model. The vehicle group refers to the injection of Matrigel, a degradable matrix with temperature sensitivity and biocompatibility75,76. B The representative MRI images on week 3 and 6 (n = 5, biological replicates and quantified in (D)). C The Representative X-ray images on week 3 and 6 (n = 5, biological replicates and quantified in (E)). D Quantitative analysis of intervertebral disc T2 signal intensity in MRI (Data are presented as mean values ± SD, n = 5, biological replicates). E Quantitative analysis of DHI in X-ray (Data are presented as mean values ± SD, n = 5, biological replicates). The representative image showing (F) H & E and (G) Safranin O & fast green staining on week 3 and 6. The asterisk (*) shows NP tissue (scar bar: 1000 μm). Data were analyzed using the Kruskal-Wallis test, followed by Dunn’s post hoc test for multiple comparisons (D, E). Source data is provided as a Source Data file.
