Fig. 3: SNAP-5114 in GAT3 is bound to an inward-open conformation.
From: Molecular basis of human GABA transporter 3 inhibition
a Models of GAT3 inhibitor SNAP-5114, and substrate nipecotic acid and GABA. The chemical structures are drawn using ChemDraw (PerkinElmer). b Model of GAT3 (forest green cartoon) in inward-open conformation bound to SNAP-5114 (yellow sticks). Cl− is depicted as a green sphere. The location of TM1a is labeled. c Polar interaction network of SNAP-5114 at the GAT3 orthosteric pocket. d GAT3 residues participating in hydrophobic interactions with SNAP-5114’s piperidine ring (top) and lipophilic domain (bottom) are depicted as sticks.
