Fig. 6: Coarse-grained plaques display amyloid signatures designative to CAA.
From: Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
a Representative coarse-grained plaque (CGP) and cerebral amyloid angiopathy (CAA) specific average mass spectra obtained for several ROI/plaque type in one sporadic Alzheimer’s disease (sAD) and one familial Alzheimer’s disease patient (fAD). b OPLS-DA of CAA and CGP show partial separation (OPLS-DA model characteristics: R2X-0.329; R2Y-0.439; Q2-0.402). c Variable importance in Projection (VIP) scores for this OPLS-DA model. d LCO microscopy and correlative e MALDI MSI single ion maps of different Aβ species. Intensity scale: absolute Intensity 1-10, Scalebar = 50 µm. f Univariate comparison between CAA and CGP. Plots indicate single plaque/CAA values (mean ± SD). Univariate analysis was performed using two tailed Mann-Whitney U test: Aβ11pE-42 p < 0.0001, Aβ1-42 p = 0.0002, Aβ1-40 p < 0.0001, Aβ5-42 p < 0.0001, Aβ3pE-42 p = 0.0004. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Number of patients n = 10 (sAD: 5; fAD:4); number of deposits N = 21 (CAA), N = 46 (CGP).
