Fig. 3: Cardiomyocyte-specific knockout of SNAP25 contributes to the shortening of atrial APD. | Nature Communications

Fig. 3: Cardiomyocyte-specific knockout of SNAP25 contributes to the shortening of atrial APD.

From: SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

Fig. 3

a Typical optical APD50 maps and AP signal records in perfused hearts. b Statistical and quantitative analysis of APD50 in WT and SNAP25 cKO mice (n = 5 samples per group). c Representative AP traces of single atrial cardiomyocyte from WT and SNAP25 cKO mice. d Statistical and quantitative analysis of APD50 (P = 2.72e-7) and APD90 (P = 1.41e-6) in atrial cardiomyocytes from WT and SNAP25 cKO mice (n = 6 samples per group). APD, action potential duration; APD50, APD at 50% repolarization; APD90, APD at 90% repolarization. Data are presented as mean ± SEM. P values were calculated using two-tailed Student’s t-test. Source data are provided as a Source Data file.

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