Fig. 4: Experimental results verifying sensitivity of perfusion source mapping to caffeine-induced global perfusion changes. | Nature Communications

Fig. 4: Experimental results verifying sensitivity of perfusion source mapping to caffeine-induced global perfusion changes.

From: MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation

Fig. 4

a Imaged slice with two selected vein ROIs. b Selected veins overlaid on a 3D venogram. c The perfusion source maps of the selected veins at two mixing times (850 ms and 1600 ms). d Two color-coded source ROIs are selected from the perfusion source maps of each vein. A circle corresponding to each ROI is shown in its respective color in (c). Pink and purple ROIs (ROIs 1 and 3) are selected from the vein on the left, whereas the blue and green ROIs (ROIs 2 and 4) are from the vein on the right. The signal amplitude of each ROI is normalized, corrected for T1 decay and plotted at different mixing times for baseline and post-caffeine states. For all source ROIs, the peak of the baseline signal occurs earlier than post-caffeine, indicating a delayed arrival after caffeine ingestion. e The delay in arrival time was estimated for each source location in the perfusion source maps and displayed for a range of 0–400 ms. Source data are provided in ref. 54.

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