Fig. 3: PRPS2 boosts the production of newly synthesized ATP/GTP through the purine biosynthesis pathway. | Nature Communications

Fig. 3: PRPS2 boosts the production of newly synthesized ATP/GTP through the purine biosynthesis pathway.

From: PRPS2 enhances RNA m6A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms

Fig. 3: PRPS2 boosts the production of newly synthesized ATP/GTP through the purine biosynthesis pathway.

a Schematic representation of 13C stable isotope-labeled carbon flow from 13C6-glucose through the purine biosynthesis pathway. b–k Peak areas of 13C-labeled metabolites in the purine biosynthesis pathway measured by targeted LC-MS/MS from the PRPS2 or PRPS1 ectopic stable expression cell line H1299 in 1 h time-frame. The data in (b–k) were plotted as the mean ± SDs of six biological replicates. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 for multiple comparisons calculated using one-way ANOVA with Tukey’s HSD test in (b–k).

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