Fig. 3: Structural Comparison of Active and Inactive States of PAR1.
From: Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2
A Comparison of the tethered ligand-bound to active PAR1 (blue) and the antagonist vorapaxar-bound to inactive PAR1 (pink; PDB 3VW7). Inset: structural superposition illustrating the relative binding positions of vorapaxar (gray sticks) and the tethered peptide (yellow sticks) to PAR1. B Extracellular view of the comparison between tethered ligand-bound active PAR1 (blue tubes) and vorapaxar-bound inactive PAR1 (pink tubes). The tethered peptide is colored in yellow spheres, while vorapaxar is shown in gray spheres. C Key residues conformations in PAR1 bound to the antagonist vorapaxar. D Key residue conformations in PAR1 bound to the tethered ligand.
