Fig. 3: Secondary screening of functional pathways involving core protein sites.
From: VCL/ICAM-1 pathway is associated with lung inflammatory damage in SARS-CoV-2 Omicron infection
a–d Hub Proteins Analysis showing the PPI network of differentially expressed proteins in Omi-Asymptomatic vs. healthy control, Omi-Symptomatic vs. healthy control, Omi-Asymptomatic vs. ancestral, and Omi-Symptomatic vs. ancestral. e–h Function Enrichment of Hub Proteins Bar charts showing enriched Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in different comparative groups, emphasizing pathways related to actin cytoskeleton, coagulation, and immune response. i, j Heatmaps Revealing patterns and correlations of key hub proteins in asymptomatic and symptomatic groups. k, l RT-qPCR Verification Validation of VCL and ICAM-1expression levels in different patient groups. Data are presented as mean values ± SEM. n (healthy control) = 20. n (Omi-Asymptomatic) = 20. n (Omi-Symptomatic) = 20. n (ancestral) = 20. Statistical significance was determined using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. *P < 0.05. **P < 0.01.***P < 0.001.
