Fig. 6: Large-scale synthesis, derivatizations and applications of the inherently chiral calix[4]arenes. | Nature Communications

Fig. 6: Large-scale synthesis, derivatizations and applications of the inherently chiral calix[4]arenes.

From: Catalytic enantioselective synthesis of inherently chiral calix[4]arenes via organocatalyzed aromatic amination enabled desymmetrization

Fig. 6

A Large scale asymmetric synthesis. B Studies on reducing catalyst loading. C Derivatizations of the chiral calix[4]arene 3e. D Derivatizations of chiral calix[4]arene 3a. E Derivatizations of 3a into meta-amino-substituted calix[4]arenes. F Application of calix[4]arene derived catalyst in asymmetric [4 + 2] cycloaddition reaction. G Application of calix[4]arene derived catalyst in asymmetric α-amination reaction of aldehyde.

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